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Brain Tumor Eradication And Prolonged Survival
Posted: February 6th, 2012, 3:00am CST
Tocagen Inc. has announced the publication of data showing the company's investigational treatment for high grade glioma eradicates brain tumors and provides a dramatic survival benefit in mouse models of glioblastoma... -
Scientists Prove Multiple DNA Repair Defect In Monocytes
Posted: February 6th, 2012, 2:00am CST
Scientists working with Professor Bernd Kaina of the Institute of Toxicology at the Medical Center of Johannes Gutenberg University Mainz have demonstrated for the first time that certain cells circulating in human blood - so-called monocytes - are extremely sensitive to reactive oxygen species (ROS)... -
New Hope For Patients With Deadly Brain Tumor
Posted: February 6th, 2012, 2:00am CST
Jim Black is fighting the meanest, most aggressive, most common kind of brain tumor in the United States: recurrent glioblastoma multiforme (GBM). In the United States, each year, approximately 10,000 patients are affected by GBM. Now, a novel investigational device - available only at clinical trial sites - is offering new hope to these patients... -
Probable Mechanism Underlying Resveratrol Activity Revealed By NIH Study
Posted: February 5th, 2012, 2:00am CST
National Institutes of Health researchers and their colleagues have identified how resveratrol, a naturally occurring chemical found in red wine and other plant products, may confer its health benefits. The authors present evidence that resveratrol does not directly activate sirtuin 1, a protein associated with aging... -
Six-Organ Transplant Girl Goes Home Today
Posted: February 3rd, 2012, 12:00pm CST
After 100 days in hospital and undergoing a complicated 6-organ transplant, 9-year-old Alannah Shevenell, from Maine, leaves Boston Children's Hospital today and goes home. Alannah has been treated for a rare form of cancer; an inflammatory myofibroblastic tumor continued to grow after all possible treatments failed, and was compromising her internal organs. A team of surgeons, led by Dr... -
Device Provides A Platform For Viewing Cancer Cells And Other Macromolecules In Dynamic, Life-Sustaining Liquid Environments
Posted: February 3rd, 2012, 3:00am CST
A photograph of a polar bear in captivity, no matter how sharp the resolution, can never reveal as much about behavior as footage of that polar bear in its natural habitat. The behavior of cells and molecules can prove even more elusive... -
Chaos In The Cell's Command Center
Posted: February 3rd, 2012, 2:00am CST
A defective operating system is never a good thing. Like computers, our cells depend on operating systems to drive normal functions. Gene expression programs comprise the software code our cells rely on, with each cell type controlled by its own program. Corrupted programs can trigger disease... -
For Brain Cancer - A Thought-Provoking New Therapeutic Target?
Posted: February 3rd, 2012, 2:00am CST
Glioblastoma multiforme (GBM) is the most common of all malignant brain tumors that originate in the brain. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. New therapeutic approaches are therefore much needed... -
Cancer Patients' Health Benefits From Physical Activity
Posted: February 2nd, 2012, 12:00pm CST
According to an investigation published on bmj.com, cancer patients who have completed their primary cancer-related treatment, who engage in physical activity, can enhance their health. Earlier studies discovered that individuals with cancer anticipate to return to normal daily activities after completing their primary cancer-related treatment... -
News From The Journal Of Clinical Investigation: Feb. 1, 2012
Posted: February 2nd, 2012, 3:00am CST
ONCOLOGY: Answers to age-old questions surrounding fat cell cancer Myxoid round cell liposarcoma (MRCLS) is a cancerous tumor that typically arises in deep fat tissues of the limbs or abdomen. It was shown almost 20 years ago to be characterized by a chromosomal change that generates a fusion protein known as TLS:CHOP... -
Researchers Develop Novel Drug Delivery System
Posted: February 2nd, 2012, 2:00am CST
Long duration, controllable drug delivery is of wide interest to medical researchers and clinicians, particularly those seeking to improve treatment for patients with chronic pain or to prevent cancer recurrence after surgery... -
Liquid Lasers May Better Detect Genes Linked To Cancer
Posted: February 2nd, 2012, 2:00am CST
Using a liquid laser, University of Michigan researchers have developed a better way to detect the slight genetic mutations that might predispose a person to a particular type of cancer or other diseases. Their results are published in the current edition of the German journal Angewandte Chemie. This work could advance understanding of the genetic basis of diseases... -
Preclinical Study Identifies New Target For Cancer Therapy
Posted: February 1st, 2012, 3:00am CST
Scientists from the Ludwig Institute for Cancer Research (LICR) in Brussels identified a new target for cancer therapy, an enzyme which prevents the immune system from recognizing and destroying certain types of tumors. Called tryptophan 2,3-dioxygenase or TDO, the enzyme works by depriving immune cells of tryptophan, an amino acid essential to their activity... -
Defects In The Packaging Of DNA In Malignant Brain Tumors
Posted: February 1st, 2012, 2:00am CST
Glioblastomas grow extremely aggressively into healthy brain tissue and, moreover, are highly resistant to radiation therapy and chemotherapy. Therefore, they are regarded as the most malignant type of brain tumor. Currently available treatment methods are frequently not very effective against this type of cancer... -
Barrett's Patients Who Smoke Are Twice As Likely To Develop Esophageal Cancer
Posted: February 1st, 2012, 2:00am CST
Barrett's esophagus (BE) patients who smoke tobacco are at a two-fold increased risk of developing esophageal cancer, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. BE patients who smoke also double their risk for developing advanced precancerous cells... -
Genetic Breakthrough For Brain Cancer In Children
Posted: February 1st, 2012, 2:00am CST
An international research team led by the Research Institute of the McGill University Health Centre (RI MUHC) has made a major genetic breakthrough that could change the way pediatric cancers are treated in the future... -
Childhood Brain Tumors Linked To Newly Discovered Mutations
Posted: January 31st, 2012, 11:00am CST
A recent study published in the online edition of the scientific journal Nature Genetics of rare, lethal childhood tumors of the brainstem has revealed that almost 80% of tumors contain gene mutations that have previously not been associated with cancer. According to early evidence, gene alterations also implicate other aggressive pediatric brain tumors... -
Immunological Mechanisms Of Oncolytic Adenoviral Therapy
Posted: January 31st, 2012, 2:00am CST
Cancer is one of the most common causes of death in humans. The conventional cancer therapies include surgery, radiotherapy, chemotherapy, and targeting therapies, which are intended to directly destroy and eliminate tumor cells. These treatments often fail, resulting in tumor metastasis and recurrence. Therefore, there is a critical need for novel cancer therapies... -
Research Scientists Illuminate Cancer Cells' Survival Strategy During Dangerous Dissemination
Posted: January 31st, 2012, 2:00am CST
A team led by scientists at The Scripps Research Institute has discovered key elements of a strategy commonly used by tumor cells to survive when they spread to distant organs. The finding could lead to drugs that could inhibit this metastasis in patients with tumors... -
Major Challenge Of Drug Delivery Addressed By Researchers' Innovation
Posted: January 31st, 2012, 2:00am CST
A new physical form of proteins developed by researchers at The University of Texas at Austin could drastically improve treatments for cancer and other diseases, as well as overcome some of the largest challenges in therapeutics: delivering drugs to patients safely, easily and more effectively... -
New Drug Release Mechanism Developed That Utilizes 3D Superhydrophobic Materials
Posted: January 31st, 2012, 2:00am CST
According to a recent study, there is a new mechanism of drug release using 3D superhydrophobic materials that utilizes air as a removable barrier to control the rate at which drug is released. The study was electronically published in the Journal of the American Chemical Society... -
New Vaccine Approach Discovered For The Treatment Of Cancer
Posted: January 30th, 2012, 3:00am CST
Scientists in Trinity College Dublin, Ireland, have developed a new vaccine to treat cancer at the pre-clinical level. The research team led by Professor Kingston Mills, Professor of Experimental Immunology at Trinity College Dublin discovered a new approach for treating the disease based on manipulating the immune response to malignant tumours... -
Mutations Tied To Aggressive Childhood Brain Tumors Revealed By Cancer Sequencing Initiative
Posted: January 30th, 2012, 3:00am CST
Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer. Early evidence suggests the alterations play a unique role in other aggressive pediatric brain tumors as well. The findings from the St... -
Stress-Induced Genomic Instability Facilitates Rapid Cellular Adaption In Yeast
Posted: January 30th, 2012, 3:00am CST
Cells trying to keep pace with constantly changing environmental conditions need to strike a fine balance between maintaining their genomic integrity and allowing enough genetic flexibility to adapt to inhospitable conditions... -
Study Finds Mysterious Protein's Entwined Arm Movements May Control Fate Of Potentially Toxic Payload
Posted: January 30th, 2012, 2:00am CST
Like a magician employing sleight of hand, the protein mitoNEET - a mysterious but important player in diabetes, cancer and aging - draws the eye with a flurry of movement in one location while the subtle, more crucial action takes place somewhere else... -
Genetic Variation Revealed That Raises A Risk Linked To Bisphosphonates
Posted: January 30th, 2012, 2:00am CST
Researchers at the Columbia University College of Dental Medicine have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class of osteoclastic inhibitors. The discovery paves the way for a genetic screening test to determine who can safely take these drugs... -
Patient Care Could Be Revolutionized By Diagnostic Brain Tumor Test
Posted: January 30th, 2012, 2:00am CST
Researchers at UT Southwestern Medical Center have developed what they believe to be the first clinical application of a new imaging technique to diagnose brain tumors. The unique test could preclude the need for surgery in patients whose tumors are located in areas of the brain too dangerous to biopsy... -
Head And Neck Cancer Cells Destroyed By Grape Seed Extract, But Healthy Cells Are Unharmed
Posted: January 30th, 2012, 2:00am CST
Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million. A study published in the journal Carcinogenesisshows that in both cell lines and mouse models, grape seed extract (GSE) kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed... -
Increased Risk For Transplant Patients Who Develop Head & Neck Cancer
Posted: January 30th, 2012, 2:00am CST
Transplant patients who develop head and neck cancer are more likely to be non-smokers and non-drinkers, and less likely than their non-transplant counterparts to survive past one year of diagnosis, according to a new study from Henry Ford Hospital in Detroit... -
Head And Neck Cancer Recurrences Detected Earlier By Routine Follow-Up Scans
Posted: January 29th, 2012, 2:00am CST
Routine use of positron emission tomography/computed tomography (PET/CT) scans in head and neck cancer patient follow-up can detect local recurrences before they become clinically apparent and may improve the outcome of subsequent salvage therapy, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM... -
US Cancer Screening Below National Targets
Posted: January 28th, 2012, 5:00am CST
The percentage of people screened for cancer in the US remains below national targets for 2020, with rates lower among Asian and Hispanic Americans than other groups, according to a new report by the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI) released on Friday. The report shows that in 2010, the screening rate for breast cancer was 72... -
Researchers Discover New Therapeutic Target To Combat Liver Cancer
Posted: January 28th, 2012, 2:00am CST
Researchers at CIC Biogune, the Cooperative Centre for Research into Biosciences and led by Dr. Maria Luz Martinez Chantar, have found a strong relationship between high levels of Hu antigen R (HuR) protein and the malignancy of Hepatocellular Carcinoma, through a novel molecular process in the investigation of this pathology and known as neddylation... -
Inlyta (axitinib) Approved For Advanced Kidney Cancer, USA
Posted: January 27th, 2012, 4:00pm CST
The US FDA has approved Inlyta (axitinib) for the treatment of advanced renal cell carcinoma, a type of kidney cancer, in patients with whom other drugs have not been effective, the FDA (Food and Drug Administration) announced today. Inlyta is made and marketed by pharmaceutical giant Pfizer Inc... -
Cancer Screening Rates Low Among Ethnic Groups, USA
Posted: January 27th, 2012, 12:00pm CST
Not only are relatively few Americans screened for cancer, but there are considerable disparities between ethnic and racial groups in the country, says a new report issued by NCI (National Cancer Institute) and the CDCF (Centers for Disease Control and Prevention). The authors added that screening rates are especially low among Hispanic and Asian Americans... -
Erlotinib Dose-Adjusted For Smoking Status Effective As First Treatment For Head And Neck Cancer
Posted: January 27th, 2012, 6:00am CST
Head and neck cancers respond well to the anti-cancer drug erlotinib when it is administered before surgery and a stronger dose is given to patients who smoke, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM... -
In HIV-Positive Patients, Standard Treatments For Head And Neck Cancer Are Less Effective
Posted: January 27th, 2012, 6:00am CST
Radiation therapy with or without chemotherapy is less effective for patients with HIV when compared to the recurrence and overall survival rates in patients who do not have HIV, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM. Treating head and neck cancer in HIV-positive patients is a challenge for oncologists... -
Cancer Patients' Treatment, Diagnosis Wait Time Reduced By Danish Health Care Fast Track Program
Posted: January 27th, 2012, 6:00am CST
In Denmark, implementing a national fast track system for cancer patients reduced the waiting time between a patient's initial meeting with a health care provider and their first treatment by four weeks when comparing 2010 to 2002, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM... -
Long-Term Positive Results From Radiation Plus Chemotherapy For Head And Neck Cancer Patients
Posted: January 27th, 2012, 6:00am CST
A select subgroup of advanced head and neck cancer patients treated with radiation therapy plus the chemotherapy drug cisplatin had more positive outcomes than patients treated with radiation therapy alone and continued to show positive results 10 years post-treatment, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM... -
Side Effect Severity Predicted In Head And Neck Cancer Patients By Thermal Imaging To Detect Oral Temperature Changes
Posted: January 27th, 2012, 6:00am CST
Slight temperature increases of the oral mucus membranes early in a head and neck cancer patient's chemotherapy and radiation therapy (chemoradiotherapy) treatment is a predictor of severe mucositis later in treatment, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM... -
IMRT Improves Head And Neck Cancer Patients' Long-Term Quality Of Life
Posted: January 27th, 2012, 6:00am CST
Patients treated with IMRT for head and neck cancer report an increasingly better quality of life post-treatment when compared to patients receiving other forms of radiation therapy, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM... -
Removal And Storage Of Ovarian Tissue Enables Birth After Cancer Treatment
Posted: January 27th, 2012, 4:00am CST
For the first time in Germany, a woman has given birth to a child after removal and preservation of tissue from one of her ovaries. This course of action was necessary to avoid infertility owing to chemo- and radiotherapy. Andreas Müller and his colleagues report the case in the current issue of Deutsches Arzteblatt International (Dtsch Arztebl Int 2012; 109[1-2]: 8-13)... -
Mathematically Modeling Tumor-Immune Interactions To Aid Cancer Therapy
Posted: January 27th, 2012, 2:00am CST
Cancer is one of the five leading causes of death. And yet, despite decades of research, there is no standardized first-line treatment for most cancers. In addition, disappointing results from predominant second-line treatments like chemotherapy have established the need for alternative methods... -
7% Of Americans Have Oral HPV
Posted: January 26th, 2012, 11:00am CST
A study published online in JAMA on Thursday suggests 7% of men and women in the US carry the Human papillomavirus (HPV), the virus that causes a distinct form of cancer that affects the part of the throat that sits at the back of the mouth... -
Breast Cancer Survival - Why Avastin And Sutent Don't Help
Posted: January 26th, 2012, 6:00am CST
Avastin and Sutent, two cancer drugs, do not lead to longer survival in breast cancer patients, probably because they encourage an increase in the number cancer stem cells in breast tumors, according to a study carried out on mice by researchers from the Michigan Comprehensive Cancer Center, and published in the Proceedings of the National Academy of Sciences (early edition)... -
Engineered Bacteria Effectively Target Tumors, Enabling Tumor Imaging Potential In Mice
Posted: January 26th, 2012, 4:00am CST
Tumor-targeted bioluminescent bacteria have been shown for the first time to provide accurate 3D images of tumors in mice, further advancing the potential for targeted cancer drug delivery, according to a study published in the Jan. 25 issue of the online journal PLoS ONE... -
Solving The Mystery Of Membrane Fusion
Posted: January 26th, 2012, 2:00am CST
The many factors that contribute to how cells communicate and function at the most basic level are still not fully understood, but researchers at Baylor College of Medicine have uncovered a mechanism that helps explain how intracellular membranes fuse, and in the process, created a new physiological membrane fusion model. The findings appear in the current edition of the journal PLoS Biology... -
Potential New Pathway Can Overcome Glioblastoma Resistance
Posted: January 25th, 2012, 11:00am CST
Glioblastoma is the most prevalent and most aggressive malignant brain tumor in humans, and is one of the most resistant to current treatments. Individuals with the disease typically survive around 15 months. Earlier research concentrated on activating the (apoptosis) cell death pathway through therapeutic agents like tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)... -
Study Of Plant Hormone Could Have Far-Reaching Implications For Cell Biology And Disease Research
Posted: January 25th, 2012, 3:00am CST
A recent Van Andel Research Institute (VARI) study published in the journal Science investigating the molecular structure and function of an essential plant hormone could profoundly change our understanding of a key cell process, and might ultimately lead to the development of new drugs for a variety of diseases... -
Possible New Pathway Can Overcome Glioblastoma Resistance
Posted: January 25th, 2012, 3:00am CST
Glioblastoma, a lethal brain cancer, is one of the most resistant to available therapies and patients typically live approximately 15 months... -
Could The Key To Cancer Be Patterns Of Chromosome Abnormality?
Posted: January 25th, 2012, 2:00am CST
A healthy genome is characterized by 23 pairs of chromosomes, and even a small change in this structure - such as an extra copy of a single chromosome - can lead to severe physical impairment. So it's no surprise that when it comes to cancer, chromosomal structure is frequently a contributing factor, says Prof. Ron Shamir of the Blavatnik School of Computer Science at Tel Aviv University...