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The 'ROCK'y Road To Diabetic Kidney Failure
Posted: February 9th, 2012, 4:00am CST
A protein kinase known as ROCK1 can exacerbate an important process called fission in the mitochondria, the power plants of cells, leading to diabetic kidney disease, said researchers from Baylor College of Medicine in a report that appears online in the journal Cell Metabolism. (ROCK1 stands for (Rho-associated coiled-coil containing protein kinase 1... -
Anti-Obesity Drug Now In Clinical Trials May Cause Rapid Bone Loss
Posted: February 9th, 2012, 2:00am CST
An endocrine hormone used in clinical trials as an anti-obesity and anti-diabetes drug causes significant and rapid bone loss in mice, raising concerns about its safe use, UT Southwestern Medical Center researchers have shown... -
Researchers Pave The Way For Improving Treatment For Type 2 Diabetes
Posted: February 9th, 2012, 2:00am CST
In a study published last week in the prestigious Proceedings of the National Academy of Sciences of the United States of America, a team led by Dr. Vincent Poitout of the University of Montreal Hospital Research Centre (CRCHUM)* has made an important step forward in understanding how insulin secretion is regulated in the body... -
Breathalyzer Device Identifies Glucose Metabolism Problems Accurately
Posted: February 8th, 2012, 12:00pm CST
According to a study published in the peer-reviewed journal Metabolism, a "breathalyzer"-like technology, currently under development at the University of Wisconsin-Madison, may help diagnose diseases in the future. The study shows a simple, but sensitive technique, that can identify normal and disease-state glucose metabolism by a fast analysis of exhaled air or blood... -
Early Signs Of Disease Detected By Metabolic 'Breathalyzer'
Posted: February 8th, 2012, 3:00am CST
The future of disease diagnosis may lie in a "breathalyzer"-like technology currently under development at the University of Wisconsin-Madison. New research published online in February in the peer-reviewed journal Metabolism demonstrates a simple but sensitive method that can distinguish normal and disease-state glucose metabolism by a quick assay of blood or exhaled air... -
Zinc Control Mechanisms Could Be Key To Aggressive Breast Cancer Treatments
Posted: February 8th, 2012, 2:00am CST
The body's control mechanisms for delivering zinc to cells could be key to improving treatment for some types of aggressive breast cancer. New research by Cardiff University and King's College London has identified the switch which releases zinc into cells, with important implications for a number of diseases. Zinc has long been known to play a vital part in human health... -
Based On CE Analysis Of Oral Medications, ACP Recommends Metformin To Treat Type 2 Diabetes
Posted: February 7th, 2012, 3:00am CST
The American College of Physicians (ACP) recommends that clinicians add metformin as the initial drug treatment for most patients with type 2 diabetes when lifestyle modifications such as diet, exercise, and weight loss have failed to adequately improve high blood sugar... -
News From The Annals Of Internal Medicine: Feb. 7 2012
Posted: February 7th, 2012, 3:00am CST
1... -
Taste Receptors Discovered In Pancreatic Beta Cells Can Sense Fructose And Stimulate Insulin Secretion
Posted: February 7th, 2012, 3:00am CST
Taste receptors on the tongue help us distinguish between safe food and food that's spoiled or toxic. But taste receptors are now being found in other organs, too... -
One In Ten Cases Of Diabetes Goes Untreated
Posted: February 7th, 2012, 2:00am CST
Rates of diabetes vary widely across developing countries worldwide, according to a new analysis led by Dr. Longjian Liu of Drexel University's School of Public Health. Worldwide, four in five people with diabetes now live in developing countries... -
Elevated Glucose Associated With Undetected Heart Damage
Posted: February 6th, 2012, 2:00am CST
A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health suggests that hyperglycemia (high blood sugar) injures the heart, even in patients without a history of heart disease or diabetes... -
Probable Mechanism Underlying Resveratrol Activity Revealed By NIH Study
Posted: February 5th, 2012, 2:00am CST
National Institutes of Health researchers and their colleagues have identified how resveratrol, a naturally occurring chemical found in red wine and other plant products, may confer its health benefits. The authors present evidence that resveratrol does not directly activate sirtuin 1, a protein associated with aging... -
Exercise In Low Oxygen Environment May Result In Improved Insulin Sensitivity
Posted: February 5th, 2012, 2:00am CST
Intermittent exercise with and without low oxygen concentrations (or hypoxia) can improve insulin sensitivity in type 2 diabetics, however exercise while under hypoxic conditions provides greater improvements in glycemic control than intermittent exercise alone, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM)... -
Memory Function - Decaffeinated Coffee May Help
Posted: February 4th, 2012, 12:00pm CST
Drinking decaffeinated coffee may improve brain energy metabolism associated with diabetes type 2, according to a study published in Nutritional Neuroscience and carried out by researchers at Mount Sinai School of Medicine. Brain energy metabolism is a dysfunction with a known risk factor for dementia and other neurodegenerative disorders like Alzheimer's disease... -
Link Between Insulin Resistance And Brain Health In Elderly
Posted: February 3rd, 2012, 3:00am CST
New research from Uppsala University shows that reduced insulin sensitivity is linked to smaller brain size and deteriorated language skills in seniors. The findings are now published in the scientific journal Diabetes Care. The main hormonal function of insulin is to support the uptake and use of glucose in muscles and fat tissues... -
Metabolic Side Effects Such As Obesity And Diabetes Caused By Antipsychotic Medications
Posted: February 3rd, 2012, 3:00am CST
In 2008, roughly 14.3 million Americans were taking antipsychotics - typically prescribed for bipolar disorder, schizophrenia, or a number of other behavioral disorders - making them among the most prescribed drugs in the U.S... -
Seasonal Changes May Influence The Efficacy Of Vaccination Against Diabetes
Posted: February 3rd, 2012, 2:00am CST
The development of a medicine for patients with type 1 diabetes mellitus, based on autoantigen GAD65, received a setback following crucial clinical phase 3 trials that failed to show significant effects. One possible explanation may be seasonal variations in the immune system, claim those responsible for the study that was published in the New England Journal of Medicine (NEJM)... -
Brain Energy Metabolism Improved By Decaffeinated Coffee
Posted: February 2nd, 2012, 3:00am CST
Researchers from Mount Sinai School of Medicine have discovered that decaffeinated coffee may improve brain energy metabolism associated with type 2 diabetes. This brain dysfunction is a known risk factor for dementia and other neurodegenerative disorders like Alzheimer's disease. The research is published online in Nutritional Neuroscience... -
Biological Time-Keeper Linked To Diabetes
Posted: February 1st, 2012, 2:00am CST
Researchers in Lille and Paris demonstrated that mutations in the melatonin receptor gene (melatonin or the "hormone of darkness" induces sleep) lead to an almost sevenfold increase in the risk of developing diabetes. This research, which was published in Nature Genetics on 29 January 2012, could contributed to the development of new drugs for the treatment or prevention of this metabolic disease... -
Study Of Genetic Regulation Of Metabolomic Biomarkers - Paths To Cardiovascular Diseases And Type 2 Diabetes
Posted: January 30th, 2012, 3:00am CST
In a study into the genetic variance of human metabolism, researchers have identified thirty one regions of the genome that were associated with levels of circulating metabolites, i.e., small molecules that take part in various chemical reactions of human body... -
New Genetic Study Links Body Clock Receptor To Diabetes
Posted: January 30th, 2012, 3:00am CST
A study published in Nature Genetics has found new evidence for a link between the body clock hormone melatonin and type 2 diabetes. The study found that people who carry rare genetic mutations in the receptor for melatonin have a much higher risk of type 2 diabetes... -
Study Finds Mysterious Protein's Entwined Arm Movements May Control Fate Of Potentially Toxic Payload
Posted: January 30th, 2012, 2:00am CST
Like a magician employing sleight of hand, the protein mitoNEET - a mysterious but important player in diabetes, cancer and aging - draws the eye with a flurry of movement in one location while the subtle, more crucial action takes place somewhere else... -
Amylin's Once-Weekly Diabetes Injection Finally Wins FDA Approval
Posted: January 28th, 2012, 5:00pm CST
On Friday, the US Food and Drug Administration finally approved Amylin Pharmaceutical's diabetes drug Bydureon, which provides glycemic control for diabetes type 2 in a once-weekly injection. The approval follows two earlier rejections in 2010, when the FDA asked the company to go back and carry out a new trial of the drug's effect on heart rhythm... -
Animal Fat Consumption Before Conception Linked To Gestational Diabetes Risk
Posted: January 28th, 2012, 2:00am CST
Women who consumed a diet high in animal fat and cholesterol before pregnancy were at higher risk for gestational diabetes than women whose diets were lower in animal fat and cholesterol, according to researchers at the National Institutes of Health and Harvard University. Gestational diabetes is a form of diabetes seen during pregnancy... -
Women With Diabetes Experience More Hearing Problems
Posted: January 27th, 2012, 12:00pm CST
A new study from Henry Ford Hospital in Detroit, presented at the annual Triological Society's Combined Sections Meeting, on January 26 in Miami Beach, shows that diabetes is likely to cause a greater degree of hearing loss in women as they get older, particularly if the diabetes is not well controlled with medication... -
Lower Limb Amputation Rates Associated With Diabetes Drop, US
Posted: January 27th, 2012, 2:00am CST
An investigation by the Centers for Disease Control and Prevention, found that between 1996 and 2008, the amount of leg and foot amputations among U.S. individuals, aged 40+ with diagnosed diabetes, decreased by 65%. The study, entitled "Declining Rates of Hospitalization for Non-traumatic Lower-Extremity Amputation in the Diabetic Population Aged 40 years or Older: U.S... -
Large Drop In Leg And Foot Amputations Among Adult Diabetics, CDC
Posted: January 26th, 2012, 6:00am CST
There has been a large drop in the rate of leg and foot amputations among Americans aged 40 and over with diagnosed diabetes, according to a new study by the US Centers for Disease Control and Prevention (CDC) published in the February issue of Diabetes Care. The study reports that between 1996 and 2008 the rate of such amputations fell by 65%... -
Patients With Diabetes Benefit From Lifestyle Counseling In Primary Care Setting
Posted: January 26th, 2012, 2:00am CST
Lifestyle counseling, practiced as part of routine care for people with diabetes, helps people more quickly lower blood glucose, blood pressure and cholesterol levels and keep them under control, according to a large, long-term study published in the February issue of Diabetes Care... -
Brown Fat - Keeps You Warm And Keeps You Slim
Posted: January 25th, 2012, 2:00pm CST
People with more brown fat seem better able to stay warm when it is cold, Canadian researchers reported in the Journal of Clinical Investigation. They added that the findings of their study could eventually be used to find ways of fighting obesity. Not much has been known about brown fat, a type of good fat, until recently... -
High-Cost Screening Instead Of More Effective Tests Usually Offered To Neuropathy Patients
Posted: January 25th, 2012, 3:00am CST
Researchers at the University of Michigan analyzed the tremendous cost of diagnosing peripheral neuropathy and found that less expensive, more effective tests are less likely to be used... -
Increase In Physician Referrals Could Lead To Increase In Health Care Costs
Posted: January 25th, 2012, 3:00am CST
Physician referral rates in the United States doubled between 1999 and 2009, a new study finds, an increase that likely contributes to the rising costs of health care. The increase in referral rates coincides with an increase in chronic conditions such as Type 2 diabetes... -
Nurturing Mothers Rear Physically Healthier Adults
Posted: January 25th, 2012, 2:00am CST
Nurturing mothers have garnered accolades for rescuing skinned knees on the playground and coaxing their children to sleep with lullabies. Now they're gaining merit for their offspring's physical health in middle age... -
Saliva Test Could Replace Blood Test For Diabetics
Posted: January 25th, 2012, 2:00am CST
Engineers at Brown University have designed a biological device that can measure glucose concentrations in human saliva. The technique could eliminate the need for diabetics to draw blood to check their glucose levels. The biochip uses plasmonic interferometers and could be used to measure a range of biological and environmental substances. Results are published in Nano Letters... -
Cellular Degradation May Determine The Health Benefits Of Exercise
Posted: January 24th, 2012, 2:00am CST
The health benefits of exercise on blood sugar metabolism may come from the body's ability to devour itself, UT Southwestern Medical Center researchers report in the journal Nature. Autophagy is a process by which a cell responds to starvation and other stresses by degrading damaged or unneeded parts of itself to produce energy. It is sometimes called the cell's housekeeping pathway... -
News From The Journals Of The American Society For Microbiology
Posted: January 23rd, 2012, 2:00am CST
Saturated Fatty Acids Lead to Mitochondrial Dysfunction and Insulin Resistance Excessive levels of certain saturated fatty acids cause mitochondria to fragment, leading to insulin resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal Molecular and Cellular Biology... -
Chemists Unlock Potential Target For Drug Development
Posted: January 23rd, 2012, 2:00am CST
A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University chemists. A team led by Dana Spence of MSU's Department of Chemistry has revealed a way to isolate and test the receptor known as P2X1... -
TNF Receptor Levels In The Blood Warn Of Kidney Problems For Individuals With Type 1 And Type 2 Diabetes
Posted: January 21st, 2012, 2:00am CST
Levels of certain blood proteins indicate which diabetes patients will likely develop life-threatening kidney problems in the future, according to two studies appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results could help physicians protect the kidney health of patients with diabetes years before any visible signs of trouble arise... -
The Mystery Of An Old Diabetes Drug That May Reduce Cancer Risk: Research Opens Exciting New Avenues In Cancer Prevention
Posted: January 20th, 2012, 3:00am CST
In 2005, news first broke that researchers in Scotland found unexpectedly low rates of cancer among diabetics taking metformin, a drug commonly prescribed to patients with Type II diabetes. Many follow-up studies reported similar findings, some suggesting as much as a 50-per-cent reduction in risk... -
32 Million Americans Have Autoantibodies That Target Their Own Tissues
Posted: January 17th, 2012, 2:00am CST
More than 32 million people in the United States have autoantibodies, which are proteins made by the immune system that target the body's tissues and define a condition known as autoimmunity, a study shows... -
New Light Shed On Link Between 'Killer Cells' And Diabetes
Posted: January 17th, 2012, 2:00am CST
Killer T-cells in the human body which help protect us from disease can inadvertently destroy cells that produce insulin, new research has uncovered. The study provides the first evidence of this mechanism in action and could offer new understanding of the cause of Type 1 diabetes... -
Discovery Of A New Muscle Hormone Might Allow Benefits Of Exercising To Be Induced
Posted: January 16th, 2012, 5:00pm CST
Researchers at the Dana-Farber Cancer Institute say they have isolated a previously unknown hormone they found in muscle cells. They sat that the protein serves as a chemical messenger triggering many of the key health benefits of exercising... -
"Smart" Nanotherapeutics Developed That Deliver Drugs Directly To Pancreas
Posted: January 16th, 2012, 2:00am CST
A research collaboration between the Wyss Institute for Biologically Inspired Engineering at Harvard University and Children's Hospital Boston has developed "smart" injectable nanotherapeutics that can be programmed to selectively deliver drugs to the cells of the pancreas... -
Researchers Identify Pivotal Immune Cell In Type 1 Diabetes In Humans
Posted: January 15th, 2012, 2:00am CST
Researchers at the La Jolla Institute for Allergy & Immunology have proven - for the first time in human tissues - the specific immune system T cells which trigger the destruction of type 1 diabetes in the pancreas... -
Scientists Isolate Hormone That Triggers Health Benefits Of Exercise
Posted: January 14th, 2012, 4:00am CST
An international team of scientists has isolated a natural hormone or chemical messenger in muscle cells that triggers some of the important health benefits of exercise. They have named it "irisin", after the Greek messenger goddess, and believe it is a promising candidate for developing drugs to treat diabetes, obesity and maybe even cancer... -
Coffee Drinkers At Reduced Risk Of Type 2 Diabetes
Posted: January 13th, 2012, 3:00am CST
Why do heavy coffee drinkers have a lower risk of developing Type 2 diabetes, a disease on the increase around the world that can lead to serious health problems? Scientists are offering a new solution to that long-standing mystery in a report in ACS' Journal of Agricultural & Food Chemistry... -
Protein Linking Exercise To Health Benefits Isolated By Researchers
Posted: January 13th, 2012, 2:00am CST
A team led by researchers at Dana-Farber Cancer Institute has isolated a natural hormone from muscle cells that triggers some of the key health benefits of exercise. They say the protein, which serves as a chemical messenger, is a highly promising candidate for development as a novel treatment for diabetes, obesity and perhaps other disorders, including cancer... -
Review Confirms Benefits Of More Roughage In The Diet
Posted: January 12th, 2012, 3:00am CST
We should all be eating more dietary fiber to improve our health - that's the message from a health review by scientists in India... -
Discovery Of Dance Between Protein And Binding Partners Could Influence Design Of Future Diabetes Treatments
Posted: January 12th, 2012, 2:00am CST
Using a blend of technologies, scientists from the Florida campus of The Scripps Research Institute have painted a new picture of how biochemical information can be transmitted through the modification of a protein. Previously, scientists believed that during the pairing of proteins and their binding partners ("ligands"), proteins modified their shape while ligands remained stable... -
Spotlight On Lifestyle Interventions For Diabetes
Posted: January 12th, 2012, 2:00am CST
An Emory University study* published in the January issue of Health Affairs assesses real-world lifestyle interventions to help delay or prevent the costly chronic disease that affects nearly 26 million Americans... -
New Diabetes Investigations Examine Weight-Loss Programs
Posted: January 11th, 2012, 11:00am CST
In the United States almost 26 million individuals are affected by diabetes and it is estimated that over the next 10 years 40 million more individuals in the country could develop diabetes. Furthermore, an additional 100 million people could develop an insidious prediabetic condition that frequently leads to diabetes. Often being overweight or obese triggers the condition...